{"id":9,"date":"2026-04-05T11:02:42","date_gmt":"2026-04-05T03:02:42","guid":{"rendered":"https:\/\/npi-disruptors.com\/?page_id=9"},"modified":"2026-04-05T11:02:42","modified_gmt":"2026-04-05T03:02:42","slug":"home","status":"publish","type":"page","link":"https:\/\/npi-disruptors.com\/","title":{"rendered":"Home"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">NPI Disruptor Database<\/h1>\n\n\n\n<p>A curated resource for small molecules that target nucleic acid\u2013protein interaction interfaces.<br>This database is designed to support the discovery and analysis of potential NPI disruptors collected from experimentally resolved structures.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-nowrap is-layout-flex wp-container-core-buttons-is-layout-6c531013 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\">Browse Compounds<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\">Browse Targets<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\">Download Dataset<\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Database Statistics<\/h2>\n\n\n\n<p>213 curated disruptor candidates<br>Protein targets and structural entries are being continuously organized and updated.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Explore the Database<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Browse compounds by ligand name<\/li>\n\n\n\n<li>Browse entries by PDB ID<\/li>\n\n\n\n<li>Browse targets by protein or UniProt accession<\/li>\n\n\n\n<li>Explore same-site binding candidates<\/li>\n\n\n\n<li>View downloadable datasets and annotations<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">About This Resource<\/h2>\n\n\n\n<p>The NPI Disruptor Database focuses on small molecules that bind at or near nucleic acid\u2013protein interaction interfaces.<br>It is intended as a research resource for studying potential disruptor molecules, interaction hotspots, structural features, and future machine learning applications in NPI-targeted drug discovery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contact \/ Citation<\/h2>\n\n\n\n<p>This resource is under active development.<br>For questions, collaboration, or citation information, please contact the database maintainer.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NPI Disruptor Database A curated resource for small mol [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":1,"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":10,"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/pages\/9\/revisions\/10"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}