{"id":761,"date":"2026-06-11T23:50:07","date_gmt":"2026-06-11T15:50:07","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/b6ywb8\/"},"modified":"2026-07-22T23:50:02","modified_gmt":"2026-07-22T15:50:02","slug":"b6ywb8","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/b6ywb8\/","title":{"rendered":"B6YWB8"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-761","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"B6YWB8","uniprot_related_pdbs":"6kc0,6iqw,6o74,6o7d,6o7e","protein_pocket_json":"[{\"pdb_id\":\"6iqw\",\"pockets\":[{\"compound_name\":\"ATP\",\"ligand_instance\":\"A:ATP801\",\"pocket_id\":\"6iqw_A:ATP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"Cyclic RNA cA4\",\"source_pocket_residue_count\":18,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLU527;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;E:ALA93\",\"source_hydrophobic_ratio\":0.3333,\"source_positive_ratio\":0.2222,\"mapped_uniprot_position_count\":17,\"reference_pocket_residue_count\":17,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLU527;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.2941,\"reference_positive_ratio\":0.2353,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.9751,\"global_ca_count\":703,\"pocket_rmsd_A\":0.5487,\"pocket_ca_count\":17,\"sequence_identity\":0.9986,\"overlay_cif_file\":\"6iqw__6o7b__src-A__ref-A__ATP__A_ATP801__6iqw_A_ATP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6iqw__6o7b__src-A__ref-A__ATP__A_ATP801__6iqw_A_ATP801__overlay.cif\"},{\"compound_name\":\"ATP\",\"ligand_instance\":\"A:ATP801\",\"pocket_id\":\"6iqw_A:ATP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7h\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); Cyclic DNA cA4\",\"source_pocket_residue_count\":18,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLU527;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;E:ALA93\",\"source_hydrophobic_ratio\":0.3333,\"source_positive_ratio\":0.2222,\"mapped_uniprot_position_count\":17,\"reference_pocket_residue_count\":17,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLU527;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.2941,\"reference_positive_ratio\":0.2353,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.0543,\"global_ca_count\":770,\"pocket_rmsd_A\":0.525,\"pocket_ca_count\":17,\"sequence_identity\":1.0,\"overlay_cif_file\":\"6iqw__6o7h__src-A__ref-A__ATP__A_ATP801__6iqw_A_ATP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6iqw__6o7h__src-A__ref-A__ATP__A_ATP801__6iqw_A_ATP801__overlay.cif\"},{\"compound_name\":\"ATP\",\"ligand_instance\":\"A:ATP801\",\"pocket_id\":\"6iqw_A:ATP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7i\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); RNA (5'-R(P*AP*AP*AP*A)-3')\",\"source_pocket_residue_count\":18,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLU527;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;E:ALA93\",\"source_hydrophobic_ratio\":0.3333,\"source_positive_ratio\":0.2222,\"mapped_uniprot_position_count\":17,\"reference_pocket_residue_count\":17,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLU527;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.2941,\"reference_positive_ratio\":0.2353,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.0705,\"global_ca_count\":741,\"pocket_rmsd_A\":0.5146,\"pocket_ca_count\":17,\"sequence_identity\":0.9987,\"overlay_cif_file\":\"6iqw__6o7i__src-A__ref-A__ATP__A_ATP801__6iqw_A_ATP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6iqw__6o7i__src-A__ref-A__ATP__A_ATP801__6iqw_A_ATP801__overlay.cif\"}]},{\"pdb_id\":\"6kc0\",\"pockets\":[{\"compound_name\":\"ATP\",\"ligand_instance\":\"A:ATP901\",\"pocket_id\":\"6kc0_A:ATP901\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"Cyclic RNA cA4\",\"source_pocket_residue_count\":14,\"source_pocket_residue_set\":\"A:ASP628;A:GLN244;A:GLY242;A:GLY293;A:GLY625;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR248;A:TYR623\",\"source_hydrophobic_ratio\":0.2857,\"source_positive_ratio\":0.0714,\"mapped_uniprot_position_count\":11,\"reference_pocket_residue_count\":11,\"reference_pocket_residue_set\":\"A:GLN244;A:GLY242;A:GLY293;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR248\",\"reference_hydrophobic_ratio\":0.3636,\"reference_positive_ratio\":0.0909,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":4.534,\"global_ca_count\":635,\"pocket_rmsd_A\":0.3607,\"pocket_ca_count\":11,\"sequence_identity\":0.7827,\"overlay_cif_file\":\"6kc0__6o7b__src-A__ref-A__ATP__A_ATP901__6kc0_A_ATP901__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6kc0__6o7b__src-A__ref-A__ATP__A_ATP901__6kc0_A_ATP901__overlay.cif\"}]},{\"pdb_id\":\"6o74\",\"pockets\":[{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP801\",\"pocket_id\":\"6o74_A:ANP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"Cyclic RNA cA4\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;B:LYS94\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":16,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3125,\"reference_positive_ratio\":0.25,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.4621,\"global_ca_count\":700,\"pocket_rmsd_A\":0.3102,\"pocket_ca_count\":16,\"sequence_identity\":0.9943,\"overlay_cif_file\":\"6o74__6o7b__src-A__ref-A__ANP__A_ANP801__6o74_A_ANP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o74__6o7b__src-A__ref-A__ANP__A_ANP801__6o74_A_ANP801__overlay.cif\"},{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP801\",\"pocket_id\":\"6o74_A:ANP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7h\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); Cyclic DNA cA4\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;B:LYS94\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":16,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3125,\"reference_positive_ratio\":0.25,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.0156,\"global_ca_count\":703,\"pocket_rmsd_A\":0.3665,\"pocket_ca_count\":16,\"sequence_identity\":0.9972,\"overlay_cif_file\":\"6o74__6o7h__src-A__ref-A__ANP__A_ANP801__6o74_A_ANP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o74__6o7h__src-A__ref-A__ANP__A_ANP801__6o74_A_ANP801__overlay.cif\"},{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP801\",\"pocket_id\":\"6o74_A:ANP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7i\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); RNA (5'-R(P*AP*AP*AP*A)-3')\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;B:LYS94\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":16,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3125,\"reference_positive_ratio\":0.25,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.9965,\"global_ca_count\":684,\"pocket_rmsd_A\":0.4456,\"pocket_ca_count\":16,\"sequence_identity\":0.9868,\"overlay_cif_file\":\"6o74__6o7i__src-A__ref-A__ANP__A_ANP801__6o74_A_ANP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o74__6o7i__src-A__ref-A__ANP__A_ANP801__6o74_A_ANP801__overlay.cif\"},{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP802\",\"pocket_id\":\"6o74_A:ANP802\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"Cyclic RNA cA4\",\"source_pocket_residue_count\":14,\"source_pocket_residue_set\":\"A:ASP589;A:GLN244;A:GLU267;A:GLY242;A:GLY293;A:GLY294;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR584\",\"source_hydrophobic_ratio\":0.2857,\"source_positive_ratio\":0.0714,\"mapped_uniprot_position_count\":14,\"reference_pocket_residue_count\":14,\"reference_pocket_residue_set\":\"A:ALA589;A:GLN244;A:GLU267;A:GLY242;A:GLY293;A:GLY294;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR584\",\"reference_hydrophobic_ratio\":0.3571,\"reference_positive_ratio\":0.0714,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.4621,\"global_ca_count\":700,\"pocket_rmsd_A\":0.3473,\"pocket_ca_count\":14,\"sequence_identity\":0.9943,\"overlay_cif_file\":\"6o74__6o7b__src-A__ref-A__ANP__A_ANP802__6o74_A_ANP802__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o74__6o7b__src-A__ref-A__ANP__A_ANP802__6o74_A_ANP802__overlay.cif\"},{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP802\",\"pocket_id\":\"6o74_A:ANP802\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7h\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); Cyclic DNA cA4\",\"source_pocket_residue_count\":14,\"source_pocket_residue_set\":\"A:ASP589;A:GLN244;A:GLU267;A:GLY242;A:GLY293;A:GLY294;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR584\",\"source_hydrophobic_ratio\":0.2857,\"source_positive_ratio\":0.0714,\"mapped_uniprot_position_count\":14,\"reference_pocket_residue_count\":14,\"reference_pocket_residue_set\":\"A:ASP589;A:GLN244;A:GLU267;A:GLY242;A:GLY293;A:GLY294;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR584\",\"reference_hydrophobic_ratio\":0.2857,\"reference_positive_ratio\":0.0714,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.0156,\"global_ca_count\":703,\"pocket_rmsd_A\":0.4468,\"pocket_ca_count\":14,\"sequence_identity\":0.9972,\"overlay_cif_file\":\"6o74__6o7h__src-A__ref-A__ANP__A_ANP802__6o74_A_ANP802__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o74__6o7h__src-A__ref-A__ANP__A_ANP802__6o74_A_ANP802__overlay.cif\"}]},{\"pdb_id\":\"6o7d\",\"pockets\":[{\"compound_name\":\"ATP\",\"ligand_instance\":\"A:ATP801\",\"pocket_id\":\"6o7d_A:ATP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"Cyclic RNA cA4\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;B:LYS94\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":16,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3125,\"reference_positive_ratio\":0.25,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.5303,\"global_ca_count\":701,\"pocket_rmsd_A\":0.2836,\"pocket_ca_count\":16,\"sequence_identity\":0.9957,\"overlay_cif_file\":\"6o7d__6o7b__src-A__ref-A__ATP__A_ATP801__6o7d_A_ATP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o7d__6o7b__src-A__ref-A__ATP__A_ATP801__6o7d_A_ATP801__overlay.cif\"},{\"compound_name\":\"ATP\",\"ligand_instance\":\"A:ATP801\",\"pocket_id\":\"6o7d_A:ATP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7h\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); Cyclic DNA cA4\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;B:LYS94\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":16,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3125,\"reference_positive_ratio\":0.25,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.9153,\"global_ca_count\":707,\"pocket_rmsd_A\":0.2994,\"pocket_ca_count\":16,\"sequence_identity\":1.0,\"overlay_cif_file\":\"6o7d__6o7h__src-A__ref-A__ATP__A_ATP801__6o7d_A_ATP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o7d__6o7h__src-A__ref-A__ATP__A_ATP801__6o7d_A_ATP801__overlay.cif\"},{\"compound_name\":\"ATP\",\"ligand_instance\":\"A:ATP801\",\"pocket_id\":\"6o7d_A:ATP801\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7i\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); RNA (5'-R(P*AP*AP*AP*A)-3')\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522;B:LYS94\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":16,\"reference_pocket_residue_set\":\"A:ARG524;A:ARG652;A:ASP521;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:MET545;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3125,\"reference_positive_ratio\":0.25,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.9691,\"global_ca_count\":687,\"pocket_rmsd_A\":0.4412,\"pocket_ca_count\":16,\"sequence_identity\":0.9898,\"overlay_cif_file\":\"6o7d__6o7i__src-A__ref-A__ATP__A_ATP801__6o7d_A_ATP801__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o7d__6o7i__src-A__ref-A__ATP__A_ATP801__6o7d_A_ATP801__overlay.cif\"}]},{\"pdb_id\":\"6o7e\",\"pockets\":[{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP802\",\"pocket_id\":\"6o7e_A:ANP802\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"Cyclic RNA cA4\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ALA292;A:ARG524;A:ARG652;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:PHE290;A:PHE529;A:SER542;A:VAL522;E:LYS94;E:TYR90\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":15,\"reference_pocket_residue_count\":15,\"reference_pocket_residue_set\":\"A:ALA292;A:ARG524;A:ARG652;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3333,\"reference_positive_ratio\":0.2667,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.0148,\"global_ca_count\":702,\"pocket_rmsd_A\":0.5212,\"pocket_ca_count\":15,\"sequence_identity\":0.9957,\"overlay_cif_file\":\"6o7e__6o7b__src-A__ref-A__ANP__A_ANP802__6o7e_A_ANP802__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o7e__6o7b__src-A__ref-A__ANP__A_ANP802__6o7e_A_ANP802__overlay.cif\"},{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP802\",\"pocket_id\":\"6o7e_A:ANP802\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7h\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); Cyclic DNA cA4\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ALA292;A:ARG524;A:ARG652;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:PHE290;A:PHE529;A:SER542;A:VAL522;E:LYS94;E:TYR90\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":15,\"reference_pocket_residue_count\":15,\"reference_pocket_residue_set\":\"A:ALA292;A:ARG524;A:ARG652;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3333,\"reference_positive_ratio\":0.2667,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.6024,\"global_ca_count\":771,\"pocket_rmsd_A\":0.4088,\"pocket_ca_count\":15,\"sequence_identity\":0.9974,\"overlay_cif_file\":\"6o7e__6o7h__src-A__ref-A__ANP__A_ANP802__6o7e_A_ANP802__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o7e__6o7h__src-A__ref-A__ANP__A_ANP802__6o7e_A_ANP802__overlay.cif\"},{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP802\",\"pocket_id\":\"6o7e_A:ANP802\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7i\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (38-MER); RNA (40-MER); RNA (5'-R(P*AP*AP*AP*A)-3')\",\"source_pocket_residue_count\":17,\"source_pocket_residue_set\":\"A:ALA292;A:ARG524;A:ARG652;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:PHE290;A:PHE529;A:SER542;A:VAL522;E:LYS94;E:TYR90\",\"source_hydrophobic_ratio\":0.2941,\"source_positive_ratio\":0.2941,\"mapped_uniprot_position_count\":15,\"reference_pocket_residue_count\":15,\"reference_pocket_residue_set\":\"A:ALA292;A:ARG524;A:ARG652;A:ASP523;A:ASP546;A:ASP588;A:GLY526;A:GLY587;A:HIS295;A:LEU525;A:LYS648;A:PHE290;A:PHE529;A:SER542;A:VAL522\",\"reference_hydrophobic_ratio\":0.3333,\"reference_positive_ratio\":0.2667,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.7213,\"global_ca_count\":741,\"pocket_rmsd_A\":0.4605,\"pocket_ca_count\":15,\"sequence_identity\":0.996,\"overlay_cif_file\":\"6o7e__6o7i__src-A__ref-A__ANP__A_ANP802__6o7e_A_ANP802__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o7e__6o7i__src-A__ref-A__ANP__A_ANP802__6o7e_A_ANP802__overlay.cif\"},{\"compound_name\":\"ANP\",\"ligand_instance\":\"A:ANP803\",\"pocket_id\":\"6o7e_A:ANP803\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"6o7b\",\"6o7h\",\"6o7i\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"6o7b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"Cyclic RNA cA4\",\"source_pocket_residue_count\":16,\"source_pocket_residue_set\":\"A:ASP239;A:ASP588;A:ASP589;A:GLN244;A:GLY242;A:GLY293;A:GLY294;A:GLY586;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR584\",\"source_hydrophobic_ratio\":0.25,\"source_positive_ratio\":0.0625,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":16,\"reference_pocket_residue_set\":\"A:ALA589;A:ASP239;A:ASP588;A:GLN244;A:GLY242;A:GLY293;A:GLY294;A:GLY586;A:ILE243;A:ILE247;A:LEU266;A:LYS367;A:PHE240;A:SER241;A:SER263;A:TYR584\",\"reference_hydrophobic_ratio\":0.3125,\"reference_positive_ratio\":0.0625,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.0148,\"global_ca_count\":702,\"pocket_rmsd_A\":0.4286,\"pocket_ca_count\":16,\"sequence_identity\":0.9957,\"overlay_cif_file\":\"6o7e__6o7b__src-A__ref-A__ANP__A_ANP803__6o7e_A_ANP803__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6o7e__6o7b__src-A__ref-A__ANP__A_ANP803__6o7e_A_ANP803__overlay.cif\"}]}]","protein_name":"CRISPR system single-strand-specific deoxyribonuclease Cas10\/Csm1 (subtype III-A)","protein_synonyms":"Cyclic oligoadenylate synthase; ToCsm1; ssDNase Cas10","gene_name":"csm1","gene_synonyms":"cas10; TON_0893","organism_name":"Thermococcus onnurineus (strain NA1)","uniprot_reviewed":"Reviewed","interpro_family":"IPR013408: CRISPR system single-strand-specific deoxyribonuclease Cas10\/Csm1; IPR052117: CRISPR-associated Cas10\/Csm1 subtype III-A protein","interpro_domains":"IPR000160: GGDEF domain; IPR006674: HD domain; IPR041062: Csm1, subunit domain B; IPR054767: Cas10\/Cmr2, second palm domain","interpro_homologous_superfamily":"IPR043128: Reverse transcriptase\/Diguanylate cyclase domain","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"CRISPR-Cas \/ prokaryotic antiviral defense protein","gpt_checked_class":"CRISPR-Cas \/ prokaryotic antiviral defense protein","broad_class_reason":"matched keywords: cas , cas10, cmr, crispr, csm, csm1","all_matched_classes":"CRISPR-Cas \/ prokaryotic antiviral defense protein [cas , cas10, cmr, crispr, csm, csm1] || Nuclease \/ DNA-RNA repair enzyme [deoxyribonuclease, nuclease, ribonuclease]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}