{"id":768,"date":"2026-06-11T23:50:10","date_gmt":"2026-06-11T15:50:10","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/o28025\/"},"modified":"2026-07-22T23:50:06","modified_gmt":"2026-07-22T15:50:06","slug":"o28025","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/o28025\/","title":{"rendered":"O28025"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-768","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"O28025","uniprot_related_pdbs":"3au7,4rvz,6agg","protein_pocket_json":"[{\"pdb_id\":\"3au7\",\"pockets\":[{\"compound_name\":\"AG2\",\"ligand_instance\":\"A:AG27011\",\"pocket_id\":\"3au7_A:AG27011\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"3amt\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"3amt\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (78-MER)\",\"source_pocket_residue_count\":9,\"source_pocket_residue_set\":\"A:ARG217;A:ARG401;A:ASN194;A:ASP193;A:CYS204;A:GLY215;A:PRO398;A:SER399;A:VAL203\",\"source_hydrophobic_ratio\":0.2222,\"source_positive_ratio\":0.2222,\"mapped_uniprot_position_count\":9,\"reference_pocket_residue_count\":9,\"reference_pocket_residue_set\":\"A:ARG217;A:ARG401;A:ASN194;A:ASP193;A:CYS204;A:GLY215;A:PRO398;A:SER399;A:VAL203\",\"reference_hydrophobic_ratio\":0.2222,\"reference_positive_ratio\":0.2222,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":2.1716,\"global_ca_count\":355,\"pocket_rmsd_A\":0.3156,\"pocket_ca_count\":9,\"sequence_identity\":0.9972,\"overlay_cif_file\":\"3au7__3amt__src-A__ref-A__AG2__A_AG27011__3au7_A_AG27011__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/3au7__3amt__src-A__ref-A__AG2__A_AG27011__3au7_A_AG27011__overlay.cif\"}]},{\"pdb_id\":\"4rvz\",\"pockets\":[{\"compound_name\":\"ZNN\",\"ligand_instance\":\"Z:ZNN505\",\"pocket_id\":\"4rvz_Z:ZNN505\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"3amt\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"3amt\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (78-MER)\",\"source_pocket_residue_count\":10,\"source_pocket_residue_set\":\"Z:ARG217;Z:ARG401;Z:ASN194;Z:ASP193;Z:CYS204;Z:GLU159;Z:GLY215;Z:PRO398;Z:SER399;Z:VAL203\",\"source_hydrophobic_ratio\":0.2,\"source_positive_ratio\":0.2,\"mapped_uniprot_position_count\":10,\"reference_pocket_residue_count\":10,\"reference_pocket_residue_set\":\"A:ARG217;A:ARG401;A:ASN194;A:ASP193;A:CYS204;A:GLU159;A:GLY215;A:PRO398;A:SER399;A:VAL203\",\"reference_hydrophobic_ratio\":0.2,\"reference_positive_ratio\":0.2,\"source_alignment_chain\":\"Z\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":2.3262,\"global_ca_count\":416,\"pocket_rmsd_A\":0.3956,\"pocket_ca_count\":10,\"sequence_identity\":1.0,\"overlay_cif_file\":\"4rvz__3amt__src-Z__ref-A__ZNN__Z_ZNN505__4rvz_Z_ZNN505__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/4rvz__3amt__src-Z__ref-A__ZNN__Z_ZNN505__4rvz_Z_ZNN505__overlay.cif\"}]},{\"pdb_id\":\"6agg\",\"pockets\":[{\"compound_name\":\"AG2\",\"ligand_instance\":\"Z:AG2503\",\"pocket_id\":\"6agg_Z:AG2503\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"3amt\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"3amt\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (78-MER)\",\"source_pocket_residue_count\":10,\"source_pocket_residue_set\":\"Z:ARG217;Z:ARG401;Z:ASN194;Z:ASP193;Z:CYS204;Z:GLU159;Z:GLY215;Z:PRO398;Z:SER399;Z:VAL203\",\"source_hydrophobic_ratio\":0.2,\"source_positive_ratio\":0.2,\"mapped_uniprot_position_count\":10,\"reference_pocket_residue_count\":10,\"reference_pocket_residue_set\":\"A:ARG217;A:ARG401;A:ASN194;A:ASP193;A:CYS204;A:GLU159;A:GLY215;A:PRO398;A:SER399;A:VAL203\",\"reference_hydrophobic_ratio\":0.2,\"reference_positive_ratio\":0.2,\"source_alignment_chain\":\"Z\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":2.3408,\"global_ca_count\":416,\"pocket_rmsd_A\":0.394,\"pocket_ca_count\":10,\"sequence_identity\":1.0,\"overlay_cif_file\":\"6agg__3amt__src-Z__ref-A__AG2__Z_AG2503__6agg_Z_AG2503__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/6agg__3amt__src-Z__ref-A__AG2__Z_AG2503__6agg_Z_AG2503__overlay.cif\"}]}]","protein_name":"tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS","protein_synonyms":"tRNA(Ile2) agmatidine synthetase; tRNA(Ile2)-agm2C synthetase","gene_name":"tiaS","gene_synonyms":"AF_2259","organism_name":"Archaeoglobus fulgidus (strain ATCC 49558 \/ DSM 4304 \/ JCM 9628 \/ NBRC 100126 \/ VC-16)","uniprot_reviewed":"Reviewed","interpro_family":"IPR024913: tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS; IPR053434: tRNA(Ile2) 2-agmatinylcytidine synthetase","interpro_domains":"IPR004365: OB-fold nucleic acid binding domain, AA-tRNA synthetase-type; IPR013696: TiaS, FLD domain; IPR053870: TiaS-like, TCKD domain; IPR055394: TiaS, C-terminal zinc ribbon domain","interpro_homologous_superfamily":"","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"tRNA-related enzyme","gpt_checked_class":"tRNA-related enzyme","broad_class_reason":"matched keywords: agmatinylcytidine, tias, trna","all_matched_classes":"tRNA-related enzyme [agmatinylcytidine, tias, trna]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/768","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}