{"id":770,"date":"2026-06-11T23:50:11","date_gmt":"2026-06-11T15:50:11","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/o58843\/"},"modified":"2026-07-22T23:50:07","modified_gmt":"2026-07-22T15:50:07","slug":"o58843","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/o58843\/","title":{"rendered":"O58843"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-770","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"O58843","uniprot_related_pdbs":"1it7,1it8","protein_pocket_json":"[{\"pdb_id\":\"1it7\",\"pockets\":[{\"compound_name\":\"GUN\",\"ligand_instance\":\"A:GUN602\",\"pocket_id\":\"1it7_A:GUN602\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"1j2b\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"1j2b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"tRNA(Val)\",\"source_pocket_residue_count\":11,\"source_pocket_residue_set\":\"A:ASP130;A:ASP95;A:GLN169;A:GLY195;A:GLY196;A:PHE229;A:PHE99;A:PRO132;A:SER98;A:THR127;A:VAL198\",\"source_hydrophobic_ratio\":0.3636,\"source_positive_ratio\":0.0,\"mapped_uniprot_position_count\":11,\"reference_pocket_residue_count\":22,\"reference_pocket_residue_set\":\"A:ASP130;A:ASP95;A:GLN169;A:GLY195;A:GLY196;A:PHE229;A:PHE99;A:PRO132;A:SER98;A:THR127;A:VAL198;B:ASP130;B:ASP95;B:GLN169;B:GLY195;B:GLY196;B:PHE229;B:PHE99;B:PRO132;B:SER98;B:THR127;B:VAL198\",\"reference_hydrophobic_ratio\":0.3636,\"reference_positive_ratio\":0.0,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.5232,\"global_ca_count\":576,\"pocket_rmsd_A\":0.4533,\"pocket_ca_count\":11,\"sequence_identity\":1.0,\"overlay_cif_file\":\"1it7__1j2b__src-A__ref-A__GUN__A_GUN602__1it7_A_GUN602__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/1it7__1j2b__src-A__ref-A__GUN__A_GUN602__1it7_A_GUN602__overlay.cif\"}]},{\"pdb_id\":\"1it8\",\"pockets\":[{\"compound_name\":\"PQ0\",\"ligand_instance\":\"A:PQ0602\",\"pocket_id\":\"1it8_A:PQ0602\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"1j2b\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"1j2b\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"tRNA(Val)\",\"source_pocket_residue_count\":15,\"source_pocket_residue_set\":\"A:ASP130;A:ASP95;A:GLN169;A:GLY195;A:GLY196;A:MET102;A:PHE229;A:PHE99;A:PRO132;A:SER96;A:SER98;A:THR127;A:THR167;A:VAL197;A:VAL198\",\"source_hydrophobic_ratio\":0.4,\"source_positive_ratio\":0.0,\"mapped_uniprot_position_count\":15,\"reference_pocket_residue_count\":30,\"reference_pocket_residue_set\":\"A:ASP130;A:ASP95;A:GLN169;A:GLY195;A:GLY196;A:MET102;A:PHE229;A:PHE99;A:PRO132;A:SER96;A:SER98;A:THR127;A:THR167;A:VAL197;A:VAL198;B:ASP130;B:ASP95;B:GLN169;B:GLY195;B:GLY196;B:MET102;B:PHE229;B:PHE99;B:PRO132;B:SER96;B:SER98;B:THR127;B:THR167;B:VAL197;B:VAL198\",\"reference_hydrophobic_ratio\":0.4,\"reference_positive_ratio\":0.0,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.5189,\"global_ca_count\":576,\"pocket_rmsd_A\":0.3649,\"pocket_ca_count\":15,\"sequence_identity\":1.0,\"overlay_cif_file\":\"1it8__1j2b__src-A__ref-A__PQ0__A_PQ0602__1it8_A_PQ0602__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/1it8__1j2b__src-A__ref-A__PQ0__A_PQ0602__1it8_A_PQ0602__overlay.cif\"}]}]","protein_name":"tRNA-guanine(15) transglycosylase","protein_synonyms":"7-cyano-7-deazaguanine tRNA-ribosyltransferase; Archaeal tRNA-guanine transglycosylase","gene_name":"tgtA","gene_synonyms":"PH1116","organism_name":"Pyrococcus horikoshii (strain ATCC 700860 \/ DSM 12428 \/ JCM 9974 \/ NBRC 100139 \/ OT-3)","uniprot_reviewed":"Reviewed","interpro_family":"IPR004803: tRNA-guanine transglycosylase; IPR004804: tRNA-guanine(15) transglycosylase","interpro_domains":"IPR002478: PUA domain; IPR002616: tRNA-guanine(15) transglycosylase-like; IPR004521: Uncharacterised domain CHP00451; IPR029402: tRNA-guanine transglycosylase, patch-forming domain C2; IPR032729: tRNA-guanine(15) transglycosylase, C1 domain","interpro_homologous_superfamily":"IPR015947: PUA-like superfamily; IPR036511: Queuine tRNA-ribosyltransferase-like; IPR036974: PUA domain superfamily; IPR038250: TGT, patch-forming C2 domain superfamily; IPR038370: ArcTGT, C1 domain superfamily","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"Nuclease \/ DNA-RNA repair enzyme","gpt_checked_class":"tRNA-related enzyme","broad_class_reason":"matched keywords: glycosylase","all_matched_classes":"Nuclease \/ DNA-RNA repair enzyme [glycosylase] || tRNA-related enzyme [transglycosylase, trna, trna-guanine]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}