{"id":774,"date":"2026-06-11T23:50:13","date_gmt":"2026-06-11T15:50:13","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/o92972\/"},"modified":"2026-07-22T23:50:09","modified_gmt":"2026-07-22T15:50:09","slug":"o92972","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/o92972\/","title":{"rendered":"O92972"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-774","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"O92972","uniprot_related_pdbs":"1nb6,4ry5","protein_pocket_json":"[{\"pdb_id\":\"1nb6\",\"pockets\":[{\"compound_name\":\"UTP\",\"ligand_instance\":\"A:UTP1700\",\"pocket_id\":\"1nb6_A:UTP1700\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"1nb7\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"1nb7\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"5'-R(*UP*UP*UP*U)-3'\",\"source_pocket_residue_count\":11,\"source_pocket_residue_set\":\"A:ARG48;A:ASN291;A:ASP220;A:ASP225;A:ASP318;A:CYS223;A:PHE224;A:SER282;A:SER556;A:THR221;A:THR287\",\"source_hydrophobic_ratio\":0.0909,\"source_positive_ratio\":0.0909,\"mapped_uniprot_position_count\":11,\"reference_pocket_residue_count\":22,\"reference_pocket_residue_set\":\"A:ARG48;A:ASN291;A:ASP220;A:ASP225;A:ASP318;A:CYS223;A:PHE224;A:SER282;A:SER556;A:THR221;A:THR287;B:ARG48;B:ASN291;B:ASP220;B:ASP225;B:ASP318;B:CYS223;B:PHE224;B:SER282;B:SER556;B:THR221;B:THR287\",\"reference_hydrophobic_ratio\":0.0909,\"reference_positive_ratio\":0.0909,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.4792,\"global_ca_count\":566,\"pocket_rmsd_A\":0.3967,\"pocket_ca_count\":11,\"sequence_identity\":1.0,\"overlay_cif_file\":\"1nb6__1nb7__src-A__ref-A__UTP__A_UTP1700__1nb6_A_UTP1700__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/1nb6__1nb7__src-A__ref-A__UTP__A_UTP1700__1nb6_A_UTP1700__overlay.cif\"}]},{\"pdb_id\":\"4ry5\",\"pockets\":[{\"compound_name\":\"UTP\",\"ligand_instance\":\"A:UTP1003\",\"pocket_id\":\"4ry5_A:UTP1003\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"1nb7\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"1nb7\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"5'-R(*UP*UP*UP*U)-3'\",\"source_pocket_residue_count\":16,\"source_pocket_residue_set\":\"A:ARG158;A:ARG222;A:ASN291;A:ASP220;A:ASP225;A:ASP318;A:ASP319;A:CYS223;A:ILE160;A:LEU159;A:LYS141;A:PHE224;A:SER282;A:SER556;A:THR221;A:THR287\",\"source_hydrophobic_ratio\":0.1875,\"source_positive_ratio\":0.1875,\"mapped_uniprot_position_count\":16,\"reference_pocket_residue_count\":32,\"reference_pocket_residue_set\":\"A:ARG158;A:ARG222;A:ASN291;A:ASP220;A:ASP225;A:ASP318;A:ASP319;A:CYS223;A:ILE160;A:LEU159;A:LYS141;A:PHE224;A:SER282;A:SER556;A:THR221;A:THR287;B:ARG158;B:ARG222;B:ASN291;B:ASP220;B:ASP225;B:ASP318;B:ASP319;B:CYS223;B:ILE160;B:LEU159;B:LYS141;B:PHE224;B:SER282;B:SER556;B:THR221;B:THR287\",\"reference_hydrophobic_ratio\":0.1875,\"reference_positive_ratio\":0.1875,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.5629,\"global_ca_count\":565,\"pocket_rmsd_A\":0.4438,\"pocket_ca_count\":16,\"sequence_identity\":0.9982,\"overlay_cif_file\":\"4ry5__1nb7__src-A__ref-A__UTP__A_UTP1003__4ry5_A_UTP1003__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/4ry5__1nb7__src-A__ref-A__UTP__A_UTP1003__4ry5_A_UTP1003__overlay.cif\"}]}]","protein_name":"Genome polyprotein","protein_synonyms":"","gene_name":"","gene_synonyms":"","organism_name":"Hepatitis C virus genotype 1b (strain HC-J4)","uniprot_reviewed":"Reviewed","interpro_family":"IPR002166: RNA dependent RNA polymerase, hepatitis C virus","interpro_domains":"IPR000745: Hepatitis C virus, Non-structural protein NS4a; IPR001490: Hepatitis C virus, Non-structural protein NS4b; IPR001650: Helicase, C-terminal domain-like; IPR002518: Hepatitis C virus, Non-structural protein NS2; IPR002519: Hepatitis C virus, Envelope glycoprotein E1; IPR002521: Hepatitis C virus, Core protein, C-terminal; IPR002522: Hepatitis C virus, Core protein, N-terminal; IPR002531: Hepatitis C virus, Non-structural protein E2\/NS1; IPR002868: Hepatitis C virus, Non-structural 5a protein; IPR004109: Hepatitis C virus, NS3 protease; IPR007094: RNA-directed RNA polymerase, catalytic domain; IPR011492: Non-structural protein NS3-like, DEAD-box helicase, flavivirus; IPR013192: Hepatitis C virus, Non-structural 5a protein, domain 1a; IPR013193: Hepatitis C virus non-structural 5a, 1B domain; IPR014001: Helicase superfamily 1\/2, ATP-binding domain; IPR024350: Hepatitus C virus, Non-structural 5a protein, C-terminal; IPR049913: Hepatitis C virus, p7 channel; IPR054175: NS3 RNA helicase, C-terminal helical domain","interpro_homologous_superfamily":"IPR009003: Peptidase S1, PA clan; IPR027417: P-loop containing nucleoside triphosphate hydrolase; IPR038170: NS5A domain 1a superfamily; IPR038568: Hepatitis C virus NS5A, 1B domain superfamily; IPR042205: Hepatitis C virus non-structural protein NS2, C-terminal domain; IPR042209: Hepatitis C virus non-structural protein NS2, N-terminal domain; IPR043128: Reverse transcriptase\/Diguanylate cyclase domain; IPR043502: DNA\/RNA polymerase superfamily; IPR044896: Hepatitis C virus core protein, chain A superfamily","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"CRISPR-Cas \/ prokaryotic antiviral defense protein","gpt_checked_class":"Viral replication \/ viral nucleic-acid-related protein","broad_class_reason":"matched keywords: cas","all_matched_classes":"CRISPR-Cas \/ prokaryotic antiviral defense protein [cas ] || Viral replication \/ viral nucleic-acid-related protein [hepatitis c] || DNA\/RNA polymerase and replication protein [polymerase, rna polymerase] || DNA\/RNA modification or nucleotide metabolism enzyme [nucleoside] || Other enzyme \/ miscellaneous [peptidase]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}