{"id":778,"date":"2026-06-11T23:50:14","date_gmt":"2026-06-11T15:50:14","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p01857\/"},"modified":"2026-07-22T23:50:10","modified_gmt":"2026-07-22T15:50:10","slug":"p01857","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p01857\/","title":{"rendered":"P01857"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-778","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"P01857","uniprot_related_pdbs":"5k64","protein_pocket_json":"[{\"pdb_id\":\"5k64\",\"pockets\":[{\"compound_name\":\"MES\",\"ligand_instance\":\"A:MES507\",\"pocket_id\":\"5k64_A:MES507\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"3agv\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"3agv\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3'\",\"source_pocket_residue_count\":7,\"source_pocket_residue_set\":\"A:ARG344;A:ASP401;A:GLN342;A:GLY341;A:GLY402;A:LYS340;A:TYR373\",\"source_hydrophobic_ratio\":0.0,\"source_positive_ratio\":0.2857,\"mapped_uniprot_position_count\":7,\"reference_pocket_residue_count\":14,\"reference_pocket_residue_set\":\"A:ARG344;A:ASP401;A:GLN342;A:GLY341;A:GLY402;A:LYS340;A:TYR373;B:ARG344;B:ASP401;B:GLN342;B:GLY341;B:GLY402;B:LYS340;B:TYR373\",\"reference_hydrophobic_ratio\":0.0,\"reference_positive_ratio\":0.2857,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"B\",\"global_rmsd_A\":1.4669,\"global_ca_count\":207,\"pocket_rmsd_A\":0.2848,\"pocket_ca_count\":7,\"sequence_identity\":0.9372,\"overlay_cif_file\":\"5k64__3agv__src-A__ref-B__MES__A_MES507__5k64_A_MES507__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/5k64__3agv__src-A__ref-B__MES__A_MES507__5k64_A_MES507__overlay.cif\"}]}]","protein_name":"Immunoglobulin heavy constant gamma 1","protein_synonyms":"Ig gamma-1 chain C region; Ig gamma-1 chain C region EU; Ig gamma-1 chain C region KOL; Ig gamma-1 chain C region NIE","gene_name":"IGHG1","gene_synonyms":"","organism_name":"Homo sapiens","uniprot_reviewed":"Reviewed","interpro_family":"IPR050380: Immune Recognition and Response Modulators","interpro_domains":"IPR003597: Immunoglobulin C1-set; IPR007110: Immunoglobulin-like domain","interpro_homologous_superfamily":"IPR013783: Immunoglobulin-like fold; IPR036179: Immunoglobulin-like domain superfamily","pfam_domains":"","interpro_other_entries":"IPR003006: Immunoglobulin\/major histocompatibility complex, conserved site","broad_protein_class":"Other enzyme \/ miscellaneous","gpt_checked_class":"Other enzyme \/ miscellaneous","broad_class_reason":"matched keywords: immune recognition","all_matched_classes":"Other enzyme \/ miscellaneous [immune recognition]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}