{"id":781,"date":"2026-06-11T23:50:15","date_gmt":"2026-06-11T15:50:15","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p07236\/"},"modified":"2026-07-22T23:50:12","modified_gmt":"2026-07-22T15:50:12","slug":"p07236","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p07236\/","title":{"rendered":"P07236"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-781","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"P07236","uniprot_related_pdbs":"4eo4","protein_pocket_json":"[{\"pdb_id\":\"4eo4\",\"pockets\":[{\"compound_name\":\"SSA\",\"ligand_instance\":\"A:SSA1002\",\"pocket_id\":\"4eo4_A:SSA1002\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"4yye\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"4yye\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"tRNA\",\"source_pocket_residue_count\":8,\"source_pocket_residue_set\":\"A:ARG434;A:ARG436;A:ARG439;A:GLY404;A:ILE407;A:ILE411;A:LYS408;A:VAL403\",\"source_hydrophobic_ratio\":0.375,\"source_positive_ratio\":0.5,\"mapped_uniprot_position_count\":8,\"reference_pocket_residue_count\":15,\"reference_pocket_residue_set\":\"A:ARG434;A:ARG436;A:ARG439;A:GLY404;A:ILE407;A:ILE411;A:LYS408;A:VAL403;B:ARG434;B:ARG436;B:GLY404;B:ILE407;B:ILE411;B:LYS408;B:VAL403\",\"reference_hydrophobic_ratio\":0.4,\"reference_positive_ratio\":0.4667,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.7754,\"global_ca_count\":414,\"pocket_rmsd_A\":0.3927,\"pocket_ca_count\":8,\"sequence_identity\":1.0,\"overlay_cif_file\":\"4eo4__4yye__src-A__ref-A__SSA__A_SSA1002__4eo4_A_SSA1002__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/4eo4__4yye__src-A__ref-A__SSA__A_SSA1002__4eo4_A_SSA1002__overlay.cif\"},{\"compound_name\":\"SSA\",\"ligand_instance\":\"C:SSA1002\",\"pocket_id\":\"4eo4_C:SSA1002\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"4yye\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"4yye\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"tRNA\",\"source_pocket_residue_count\":8,\"source_pocket_residue_set\":\"C:ARG434;C:ARG436;C:ARG439;C:GLY404;C:ILE407;C:ILE411;C:LYS408;C:VAL403\",\"source_hydrophobic_ratio\":0.375,\"source_positive_ratio\":0.5,\"mapped_uniprot_position_count\":8,\"reference_pocket_residue_count\":15,\"reference_pocket_residue_set\":\"A:ARG434;A:ARG436;A:ARG439;A:GLY404;A:ILE407;A:ILE411;A:LYS408;A:VAL403;B:ARG434;B:ARG436;B:GLY404;B:ILE407;B:ILE411;B:LYS408;B:VAL403\",\"reference_hydrophobic_ratio\":0.4,\"reference_positive_ratio\":0.4667,\"source_alignment_chain\":\"C\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":0.6132,\"global_ca_count\":416,\"pocket_rmsd_A\":0.3461,\"pocket_ca_count\":8,\"sequence_identity\":1.0,\"overlay_cif_file\":\"4eo4__4yye__src-C__ref-A__SSA__C_SSA1002__4eo4_C_SSA1002__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/4eo4__4yye__src-C__ref-A__SSA__C_SSA1002__4eo4_C_SSA1002__overlay.cif\"}]}]","protein_name":"Threonine--tRNA ligase, mitochondrial","protein_synonyms":"Threonyl-tRNA synthetase; ThrRS","gene_name":"MST1","gene_synonyms":"YKL194C","organism_name":"Saccharomyces cerevisiae (strain ATCC 204508 \/ S288c)","uniprot_reviewed":"Reviewed","interpro_family":"IPR002320: Threonine-tRNA ligase, class IIa","interpro_domains":"IPR002314: Aminoacyl-tRNA synthetase, class II (G\/ P\/ S\/T); IPR004154: Anticodon-binding; IPR006195: Aminoacyl-tRNA synthetase, class II; IPR033728: Threonine-tRNA ligase catalytic core domain; IPR047246: Threonine-tRNA ligase, class IIa, anticodon-binding domain","interpro_homologous_superfamily":"IPR036621: Anticodon-binding domain superfamily; IPR045864: Class II Aminoacyl-tRNA synthetase\/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"RNA-binding \/ RNA metabolism protein","gpt_checked_class":"tRNA-related enzyme","broad_class_reason":"matched keywords: rna ligase","all_matched_classes":"RNA-binding \/ RNA metabolism protein [rna ligase] || tRNA-related enzyme [aminoacyl, threonine-trna ligase, trna, trna ligase]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}