{"id":791,"date":"2026-06-11T23:50:20","date_gmt":"2026-06-11T15:50:20","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p0dtc2\/"},"modified":"2026-07-22T23:50:15","modified_gmt":"2026-07-22T15:50:15","slug":"p0dtc2","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p0dtc2\/","title":{"rendered":"P0DTC2"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-791","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"P0DTC2","uniprot_related_pdbs":"8p9y","protein_pocket_json":"[{\"pdb_id\":\"8p9y\",\"pockets\":[{\"compound_name\":\"XIO\",\"ligand_instance\":\"C:XIO1307\",\"pocket_id\":\"8p9y_C:XIO1307\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"8j1q\",\"8j26\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"8j1q\",\"reference_na_type\":\"DNA-bound\",\"reference_na_description\":\"AM032-0; AM047-0\",\"source_pocket_residue_count\":4,\"source_pocket_residue_set\":\"A:ASN343;C:ASN487;C:PHE486;C:THR478\",\"source_hydrophobic_ratio\":0.25,\"source_positive_ratio\":0.0,\"mapped_uniprot_position_count\":4,\"reference_pocket_residue_count\":4,\"reference_pocket_residue_set\":\"C:ASN343;C:ASN487;C:PHE486;C:THR478\",\"reference_hydrophobic_ratio\":0.25,\"reference_positive_ratio\":0.0,\"source_alignment_chain\":\"B\",\"reference_alignment_chain\":\"C\",\"global_rmsd_A\":1.6996,\"global_ca_count\":196,\"pocket_rmsd_A\":0.9037,\"pocket_ca_count\":4,\"sequence_identity\":1.0,\"overlay_cif_file\":\"8p9y__8j1q__src-B__ref-C__XIO__C_XIO1307__8p9y_C_XIO1307__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/8p9y__8j1q__src-B__ref-C__XIO__C_XIO1307__8p9y_C_XIO1307__overlay.cif\"},{\"compound_name\":\"XIO\",\"ligand_instance\":\"C:XIO1307\",\"pocket_id\":\"8p9y_C:XIO1307\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"8j1q\",\"8j26\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"8j26\",\"reference_na_type\":\"DNA-bound\",\"reference_na_description\":\"AM032-4; AM047-6\",\"source_pocket_residue_count\":4,\"source_pocket_residue_set\":\"A:ASN343;C:ASN487;C:PHE486;C:THR478\",\"source_hydrophobic_ratio\":0.25,\"source_positive_ratio\":0.0,\"mapped_uniprot_position_count\":4,\"reference_pocket_residue_count\":4,\"reference_pocket_residue_set\":\"C:ASN343;C:ASN487;C:PHE486;C:THR478\",\"reference_hydrophobic_ratio\":0.25,\"reference_positive_ratio\":0.0,\"source_alignment_chain\":\"B\",\"reference_alignment_chain\":\"C\",\"global_rmsd_A\":1.6992,\"global_ca_count\":196,\"pocket_rmsd_A\":0.8519,\"pocket_ca_count\":4,\"sequence_identity\":1.0,\"overlay_cif_file\":\"8p9y__8j26__src-B__ref-C__XIO__C_XIO1307__8p9y_C_XIO1307__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/8p9y__8j26__src-B__ref-C__XIO__C_XIO1307__8p9y_C_XIO1307__overlay.cif\"}]}]","protein_name":"Spike glycoprotein","protein_synonyms":"E2; Peplomer protein; S glycoprotein","gene_name":"S","gene_synonyms":"2","organism_name":"Severe acute respiratory syndrome coronavirus 2","uniprot_reviewed":"Reviewed","interpro_family":"IPR042578: Spike glycoprotein, betacoronavirus","interpro_domains":"IPR002552: Spike glycoprotein S2, coronavirus; IPR018548: Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus; IPR032500: Spike glycoprotein S1, N-terminal domain, betacoronavirus-like; IPR043607: Coronavirus spike glycoprotein S1, C-terminal; IPR044341: Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like; IPR044366: Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2; IPR044873: Spike glycoprotein S2, coronavirus, heptad repeat 1; IPR044874: Spike glycoprotein S2, coronavirus, heptad repeat 2","interpro_homologous_superfamily":"IPR036326: Spike S1 subunit, receptor binding domain superfamily, betacoronavirus; IPR043002: Spike glycoprotein, N-terminal domain superfamily; IPR043473: Spike glycoprotein S2 superfamily, coronavirus","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"Viral replication \/ viral nucleic-acid-related protein","gpt_checked_class":"Viral replication \/ viral nucleic-acid-related protein","broad_class_reason":"matched keywords: betacoronavirus, coronavirus, spike glycoprotein","all_matched_classes":"Viral replication \/ viral nucleic-acid-related protein [betacoronavirus, coronavirus, spike glycoprotein]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}