{"id":794,"date":"2026-06-11T23:50:21","date_gmt":"2026-06-11T15:50:21","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p19821\/"},"modified":"2026-07-22T23:50:16","modified_gmt":"2026-07-22T15:50:16","slug":"p19821","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p19821\/","title":{"rendered":"P19821"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-794","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"P19821","uniprot_related_pdbs":"5ktq","protein_pocket_json":"[{\"pdb_id\":\"5ktq\",\"pockets\":[{\"compound_name\":\"DCP\",\"ligand_instance\":\"A:DCP901\",\"pocket_id\":\"5ktq_A:DCP901\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"3syz\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"3syz\",\"reference_na_type\":\"DNA-bound\",\"reference_na_description\":\"(5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'); (5'-D(*AP*AP*AP*(BMN)P*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3')\",\"source_pocket_residue_count\":6,\"source_pocket_residue_set\":\"A:ARG587;A:ARG659;A:GLN613;A:HIS639;A:LYS663;A:PHE667\",\"source_hydrophobic_ratio\":0.1667,\"source_positive_ratio\":0.6667,\"mapped_uniprot_position_count\":6,\"reference_pocket_residue_count\":6,\"reference_pocket_residue_set\":\"A:ARG587;A:ARG659;A:GLN613;A:HIS639;A:LYS663;A:PHE667\",\"reference_hydrophobic_ratio\":0.1667,\"reference_positive_ratio\":0.6667,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":2.5916,\"global_ca_count\":531,\"pocket_rmsd_A\":2.0143,\"pocket_ca_count\":6,\"sequence_identity\":1.0,\"overlay_cif_file\":\"5ktq__3syz__src-A__ref-A__DCP__A_DCP901__5ktq_A_DCP901__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/5ktq__3syz__src-A__ref-A__DCP__A_DCP901__5ktq_A_DCP901__overlay.cif\"}]}]","protein_name":"DNA polymerase I, thermostable","protein_synonyms":"Taq polymerase 1","gene_name":"polA","gene_synonyms":"pol1","organism_name":"Thermus aquaticus","uniprot_reviewed":"Reviewed","interpro_family":"IPR002298: DNA polymerase A; IPR018320: DNA polymerase 1","interpro_domains":"IPR001098: DNA-directed DNA polymerase, family A, palm domain; IPR002421: 5'-3' exonuclease; IPR003583: Helix-hairpin-helix DNA-binding motif, class 1; IPR015361: Taq polymerase, thermostable, exonuclease region; IPR020045: DNA polymerase I-like, H3TH domain; IPR020046: 5'-3' exonuclease, alpha-helical arch, N-terminal","interpro_homologous_superfamily":"IPR012337: Ribonuclease H-like superfamily; IPR029060: PIN-like domain superfamily; IPR036279: 5'-3' exonuclease, C-terminal domain superfamily; IPR036397: Ribonuclease H superfamily; IPR043502: DNA\/RNA polymerase superfamily","pfam_domains":"","interpro_other_entries":"IPR008918: Helix-hairpin-helix motif, class 2; IPR019760: DNA-directed DNA polymerase, family A, conserved site","broad_protein_class":"DNA\/RNA polymerase and replication protein","gpt_checked_class":"DNA\/RNA polymerase and replication protein","broad_class_reason":"matched keywords: dna polymerase, dna-directed dna polymerase, polymerase, rna polymerase","all_matched_classes":"DNA\/RNA polymerase and replication protein [dna polymerase, dna-directed dna polymerase, polymerase, rna polymerase] || Nuclease \/ DNA-RNA repair enzyme [exonuclease, nuclease, ribonuclease]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}