{"id":798,"date":"2026-06-11T23:50:22","date_gmt":"2026-06-11T15:50:22","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p29468\/"},"modified":"2026-07-22T23:50:17","modified_gmt":"2026-07-22T15:50:17","slug":"p29468","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/p29468\/","title":{"rendered":"P29468"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-798","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"P29468","uniprot_related_pdbs":"1fa0","protein_pocket_json":"[{\"pdb_id\":\"1fa0\",\"pockets\":[{\"compound_name\":\"3AD\",\"ligand_instance\":\"A:3AD606\",\"pocket_id\":\"1fa0_A:3AD606\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"2q66\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"2q66\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"5'-R(P*AP*AP*AP*AP*A)-3'\",\"source_pocket_residue_count\":6,\"source_pocket_residue_set\":\"A:ARG186;A:ASP102;A:ASP154;A:ILE156;A:TYR87;A:VAL141\",\"source_hydrophobic_ratio\":0.3333,\"source_positive_ratio\":0.1667,\"mapped_uniprot_position_count\":6,\"reference_pocket_residue_count\":6,\"reference_pocket_residue_set\":\"A:ALA154;A:ARG186;A:ASP102;A:ILE156;A:TYR87;A:VAL141\",\"reference_hydrophobic_ratio\":0.5,\"reference_positive_ratio\":0.1667,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":3.5738,\"global_ca_count\":501,\"pocket_rmsd_A\":0.3117,\"pocket_ca_count\":6,\"sequence_identity\":0.998,\"overlay_cif_file\":\"1fa0__2q66__src-A__ref-A__3AD__A_3AD606__1fa0_A_3AD606__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/1fa0__2q66__src-A__ref-A__3AD__A_3AD606__1fa0_A_3AD606__overlay.cif\"}]}]","protein_name":"Poly(A) polymerase","protein_synonyms":"Polynucleotide adenylyltransferase; PAP","gene_name":"PAP1","gene_synonyms":"YKR002W","organism_name":"Saccharomyces cerevisiae (strain ATCC 204508 \/ S288c)","uniprot_reviewed":"Reviewed","interpro_family":"IPR014492: Poly(A) polymerase","interpro_domains":"IPR007010: Poly(A) polymerase, RNA-binding domain; IPR007012: Poly(A) polymerase, central domain; IPR048840: Poly(A) polymerase, nucleotidyltransferase domain","interpro_homologous_superfamily":"IPR011068: Nucleotidyltransferase, class I-like, C-terminal; IPR043519: Nucleotidyltransferase superfamily","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"DNA\/RNA polymerase and replication protein","gpt_checked_class":"DNA\/RNA polymerase and replication protein","broad_class_reason":"matched keywords: nucleotidyltransferase, poly(a) polymerase, polymerase","all_matched_classes":"DNA\/RNA polymerase and replication protein [nucleotidyltransferase, poly(a) polymerase, polymerase] || RNA-binding \/ RNA metabolism protein [rna-binding]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/798","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}