{"id":809,"date":"2026-06-11T23:50:27","date_gmt":"2026-06-11T15:50:27","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q38de2\/"},"modified":"2026-07-22T23:50:20","modified_gmt":"2026-07-22T15:50:20","slug":"q38de2","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q38de2\/","title":{"rendered":"Q38DE2"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-809","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"Q38DE2","uniprot_related_pdbs":"7c4b,7c47,7c4c","protein_pocket_json":"[{\"pdb_id\":\"7c47\",\"pockets\":[{\"compound_name\":\"C5P\",\"ligand_instance\":\"A:C5P403\",\"pocket_id\":\"7c47_A:C5P403\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"7c45\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"7c45\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')\",\"source_pocket_residue_count\":7,\"source_pocket_residue_set\":\"A:ALA280;A:ARG143;A:ARG180;A:ASP141;A:GLN164;A:GLY182;A:PRO279\",\"source_hydrophobic_ratio\":0.2857,\"source_positive_ratio\":0.2857,\"mapped_uniprot_position_count\":7,\"reference_pocket_residue_count\":7,\"reference_pocket_residue_set\":\"A:ALA280;A:ARG143;A:ARG180;A:ASP141;A:GLN164;A:GLY182;A:PRO279\",\"reference_hydrophobic_ratio\":0.2857,\"reference_positive_ratio\":0.2857,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":8.2149,\"global_ca_count\":290,\"pocket_rmsd_A\":0.1948,\"pocket_ca_count\":7,\"sequence_identity\":1.0,\"overlay_cif_file\":\"7c47__7c45__src-A__ref-A__C5P__A_C5P403__7c47_A_C5P403__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/7c47__7c45__src-A__ref-A__C5P__A_C5P403__7c47_A_C5P403__overlay.cif\"},{\"compound_name\":\"C5P\",\"ligand_instance\":\"A:C5P404\",\"pocket_id\":\"7c47_A:C5P404\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"7c45\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"7c45\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')\",\"source_pocket_residue_count\":6,\"source_pocket_residue_set\":\"A:ALA302;A:CYS310;A:GLU309;A:HIS305;A:LYS312;A:PHE311\",\"source_hydrophobic_ratio\":0.3333,\"source_positive_ratio\":0.3333,\"mapped_uniprot_position_count\":6,\"reference_pocket_residue_count\":6,\"reference_pocket_residue_set\":\"A:ALA302;A:CYS310;A:GLU309;A:HIS305;A:LYS312;A:PHE311\",\"reference_hydrophobic_ratio\":0.3333,\"reference_positive_ratio\":0.3333,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":8.2149,\"global_ca_count\":290,\"pocket_rmsd_A\":0.2361,\"pocket_ca_count\":6,\"sequence_identity\":1.0,\"overlay_cif_file\":\"7c47__7c45__src-A__ref-A__C5P__A_C5P404__7c47_A_C5P404__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/7c47__7c45__src-A__ref-A__C5P__A_C5P404__7c47_A_C5P404__overlay.cif\"}]},{\"pdb_id\":\"7c4b\",\"pockets\":[{\"compound_name\":\"U5P\",\"ligand_instance\":\"A:U5P405\",\"pocket_id\":\"7c4b_A:U5P405\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"7c45\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"7c45\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')\",\"source_pocket_residue_count\":5,\"source_pocket_residue_set\":\"A:CYS310;A:GLU309;A:GLY304;A:HIS305;A:PHE311\",\"source_hydrophobic_ratio\":0.2,\"source_positive_ratio\":0.2,\"mapped_uniprot_position_count\":5,\"reference_pocket_residue_count\":5,\"reference_pocket_residue_set\":\"A:CYS310;A:GLU309;A:GLY304;A:HIS305;A:PHE311\",\"reference_hydrophobic_ratio\":0.2,\"reference_positive_ratio\":0.2,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":8.1418,\"global_ca_count\":292,\"pocket_rmsd_A\":0.1768,\"pocket_ca_count\":5,\"sequence_identity\":1.0,\"overlay_cif_file\":\"7c4b__7c45__src-A__ref-A__U5P__A_U5P405__7c4b_A_U5P405__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/7c4b__7c45__src-A__ref-A__U5P__A_U5P405__7c4b_A_U5P405__overlay.cif\"}]},{\"pdb_id\":\"7c4c\",\"pockets\":[{\"compound_name\":\"5GP\",\"ligand_instance\":\"A:5GP414\",\"pocket_id\":\"7c4c_A:5GP414\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"7c45\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"7c45\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')\",\"source_pocket_residue_count\":5,\"source_pocket_residue_set\":\"A:ASN332;A:CYS333;A:GLU325;A:HIS328;A:PHE334\",\"source_hydrophobic_ratio\":0.2,\"source_positive_ratio\":0.2,\"mapped_uniprot_position_count\":5,\"reference_pocket_residue_count\":5,\"reference_pocket_residue_set\":\"A:ASN332;A:CYS333;A:GLU325;A:HIS328;A:PHE334\",\"reference_hydrophobic_ratio\":0.2,\"reference_positive_ratio\":0.2,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":8.23,\"global_ca_count\":290,\"pocket_rmsd_A\":0.314,\"pocket_ca_count\":5,\"sequence_identity\":1.0,\"overlay_cif_file\":\"7c4c__7c45__src-A__ref-A__5GP__A_5GP414__7c4c_A_5GP414__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/7c4c__7c45__src-A__ref-A__5GP__A_5GP414__7c4c_A_5GP414__overlay.cif\"},{\"compound_name\":\"5GP\",\"ligand_instance\":\"A:5GP415\",\"pocket_id\":\"7c4c_A:5GP415\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"7c45\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"7c45\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')\",\"source_pocket_residue_count\":7,\"source_pocket_residue_set\":\"A:ARG143;A:ARG144;A:ARG180;A:ASP141;A:GLN164;A:GLY182;A:PRO279\",\"source_hydrophobic_ratio\":0.1429,\"source_positive_ratio\":0.4286,\"mapped_uniprot_position_count\":7,\"reference_pocket_residue_count\":7,\"reference_pocket_residue_set\":\"A:ARG143;A:ARG144;A:ARG180;A:ASP141;A:GLN164;A:GLY182;A:PRO279\",\"reference_hydrophobic_ratio\":0.1429,\"reference_positive_ratio\":0.4286,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":8.23,\"global_ca_count\":290,\"pocket_rmsd_A\":0.1424,\"pocket_ca_count\":7,\"sequence_identity\":1.0,\"overlay_cif_file\":\"7c4c__7c45__src-A__ref-A__5GP__A_5GP415__7c4c_A_5GP415__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/7c4c__7c45__src-A__ref-A__5GP__A_5GP415__7c4c_A_5GP415__overlay.cif\"},{\"compound_name\":\"5GP\",\"ligand_instance\":\"A:5GP416\",\"pocket_id\":\"7c4c_A:5GP416\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"7c45\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"7c45\",\"reference_na_type\":\"RNA-bound\",\"reference_na_description\":\"RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')\",\"source_pocket_residue_count\":4,\"source_pocket_residue_set\":\"A:CYS310;A:GLU309;A:HIS305;A:PHE311\",\"source_hydrophobic_ratio\":0.25,\"source_positive_ratio\":0.25,\"mapped_uniprot_position_count\":4,\"reference_pocket_residue_count\":4,\"reference_pocket_residue_set\":\"A:CYS310;A:GLU309;A:HIS305;A:PHE311\",\"reference_hydrophobic_ratio\":0.25,\"reference_positive_ratio\":0.25,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":8.23,\"global_ca_count\":290,\"pocket_rmsd_A\":0.1962,\"pocket_ca_count\":4,\"sequence_identity\":1.0,\"overlay_cif_file\":\"7c4c__7c45__src-A__ref-A__5GP__A_5GP416__7c4c_A_5GP416__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/7c4c__7c45__src-A__ref-A__5GP__A_5GP416__7c4c_A_5GP416__overlay.cif\"}]}]","protein_name":"CCHC-type domain-containing protein","protein_synonyms":"","gene_name":"","gene_synonyms":"Tb09.211.3670","organism_name":"Trypanosoma brucei brucei (strain 927\/4 GUTat10.1)","uniprot_reviewed":"Unreviewed","interpro_family":"IPR052144: piRNA biogenesis EXD1-related protein","interpro_domains":"IPR001878: Zinc finger, CCHC-type; IPR002562: 3'-5' exonuclease domain","interpro_homologous_superfamily":"IPR012337: Ribonuclease H-like superfamily; IPR036397: Ribonuclease H superfamily; IPR036875: Zinc finger, CCHC-type superfamily","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"Argonaute \/ RNAi-related protein","gpt_checked_class":"RNA-binding \/ RNA metabolism protein","broad_class_reason":"matched keywords: exd1, pirna","all_matched_classes":"Argonaute \/ RNAi-related protein [exd1, pirna] || Nuclease \/ DNA-RNA repair enzyme [exonuclease, nuclease, ribonuclease] || RNA-binding \/ RNA metabolism protein [pirna biogenesis]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}