{"id":816,"date":"2026-06-11T23:50:31","date_gmt":"2026-06-11T15:50:31","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q8rqe8\/"},"modified":"2026-07-22T23:50:28","modified_gmt":"2026-07-22T15:50:28","slug":"q8rqe8","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q8rqe8\/","title":{"rendered":"Q8RQE8"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-816","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"Q8RQE8","uniprot_related_pdbs":"1zyr,2a6h","protein_pocket_json":"[{\"pdb_id\":\"9fo6\",\"pockets\":[{\"compound_name\":\"GTP\",\"ligand_instance\":\"D:GTP2006\",\"pocket_id\":\"9fo6_D:GTP2006\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"3aoh\",\"4wqs\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"3aoh\",\"reference_na_type\":\"DNA and RNA bound\",\"reference_na_description\":\"DNA (5'-D(*GP*GP*TP*CP*TP*GP*TP*AP*TP*CP*AP*CP*GP*AP*GP*CP*CP*AP*CP*CP*GP*CP*CP*GP*CP*AP*T)-3'); RNA (5'-R(*CP*CP*CP*CP*GP*GP*AP*AP*GP*AP*UP*CP*AP*UP*CP*UP*UP*CP*CP*GP*GP*GP*GP*GP*AP*U*GP*CP*GP*GP*CP*GP*G)-3')\",\"source_pocket_residue_count\":10,\"source_pocket_residue_set\":\"C:GLN567;C:HIS999;C:LYS838;C:LYS846;C:TYR998;D:ALA705;D:ARG704;D:ASP741;D:ASP743;D:PRO706\",\"source_hydrophobic_ratio\":0.2,\"source_positive_ratio\":0.4,\"mapped_uniprot_position_count\":5,\"reference_pocket_residue_count\":15,\"reference_pocket_residue_set\":\"D:ALA705;D:ARG704;D:ASP741;D:ASP743;D:PRO706;I:ALA705;I:ARG704;I:ASP741;I:ASP743;I:PRO706;N:ALA705;N:ARG704;N:ASP741;N:ASP743;N:PRO706\",\"reference_hydrophobic_ratio\":0.4,\"reference_positive_ratio\":0.2,\"source_alignment_chain\":\"D\",\"reference_alignment_chain\":\"D\",\"global_rmsd_A\":7.3013,\"global_ca_count\":1349,\"pocket_rmsd_A\":0.7142,\"pocket_ca_count\":5,\"sequence_identity\":1.0,\"overlay_cif_file\":\"9fo6__3aoh__src-D__ref-D__GTP__D_GTP2006__9fo6_D_GTP2006__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/9fo6__3aoh__src-D__ref-D__GTP__D_GTP2006__9fo6_D_GTP2006__overlay.cif\"},{\"compound_name\":\"GTP\",\"ligand_instance\":\"D:GTP2006\",\"pocket_id\":\"9fo6_D:GTP2006\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"3aoh\",\"4wqs\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"4wqs\",\"reference_na_type\":\"DNA and RNA bound\",\"reference_na_description\":\"DNA (28-MER); RNA (5'-R(P*CP*CP*AP*GP*CP*CP*GP*GP*CP*GP*CP*UP*CP*GP*CP*A)-3'); DNA (5'-D(P*GP*TP*AP*GP*CP*TP*TP*GP*TP*GP*GP*TP*AP*GP*TP*GP*AP*CP*GP*AP*G)-3')\",\"source_pocket_residue_count\":10,\"source_pocket_residue_set\":\"C:GLN567;C:HIS999;C:LYS838;C:LYS846;C:TYR998;D:ALA705;D:ARG704;D:ASP741;D:ASP743;D:PRO706\",\"source_hydrophobic_ratio\":0.2,\"source_positive_ratio\":0.4,\"mapped_uniprot_position_count\":5,\"reference_pocket_residue_count\":10,\"reference_pocket_residue_set\":\"D:ALA705;D:ARG704;D:ASP741;D:ASP743;D:PRO706;N:ALA705;N:ARG704;N:ASP741;N:ASP743;N:PRO706\",\"reference_hydrophobic_ratio\":0.4,\"reference_positive_ratio\":0.2,\"source_alignment_chain\":\"D\",\"reference_alignment_chain\":\"D\",\"global_rmsd_A\":2.954,\"global_ca_count\":1141,\"pocket_rmsd_A\":0.822,\"pocket_ca_count\":5,\"sequence_identity\":1.0,\"overlay_cif_file\":\"9fo6__4wqs__src-D__ref-D__GTP__D_GTP2006__9fo6_D_GTP2006__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/9fo6__4wqs__src-D__ref-D__GTP__D_GTP2006__9fo6_D_GTP2006__overlay.cif\"}]}]","protein_name":"DNA-directed RNA polymerase subunit beta'","protein_synonyms":"RNA polymerase subunit beta'; Transcriptase subunit beta'; RNAP subunit beta'","gene_name":"rpoC","gene_synonyms":"TTHA1812","organism_name":"Thermus thermophilus (strain ATCC 27634 \/ DSM 579 \/ HB8)","uniprot_reviewed":"Reviewed","interpro_family":"IPR012754: DNA-directed RNA polymerase, subunit beta-prime, bacterial type; IPR045867: DNA-directed RNA polymerase, subunit beta-prime","interpro_domains":"IPR000722: RNA polymerase, alpha subunit; IPR006592: RNA polymerase, N-terminal; IPR007066: RNA polymerase Rpb1, domain 3; IPR007080: RNA polymerase Rpb1, domain 1; IPR007081: RNA polymerase Rpb1, domain 5; IPR007083: RNA polymerase Rpb1, domain 4; IPR048566: DNA-directed RNA polymerase subunit beta', hybrid domain","interpro_homologous_superfamily":"IPR038120: RNA polymerase Rpb1, funnel domain superfamily; IPR042102: RNA polymerase Rpb1, domain 3 superfamily; IPR044893: RNA polymerase Rpb1, clamp domain superfamily","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"DNA\/RNA polymerase and replication protein","gpt_checked_class":"DNA\/RNA polymerase and replication protein","broad_class_reason":"matched keywords: dna-directed rna polymerase, polymerase, rna polymerase","all_matched_classes":"DNA\/RNA polymerase and replication protein [dna-directed rna polymerase, polymerase, rna polymerase]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}