{"id":821,"date":"2026-06-11T23:50:33","date_gmt":"2026-06-11T15:50:33","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q96ny9\/"},"modified":"2026-07-22T23:50:23","modified_gmt":"2026-07-22T15:50:23","slug":"q96ny9","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q96ny9\/","title":{"rendered":"Q96NY9"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-821","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"Q96NY9","uniprot_related_pdbs":"9f9l,9f9k","protein_pocket_json":"[{\"pdb_id\":\"9f9k\",\"pockets\":[{\"compound_name\":\"A1IA7\",\"ligand_instance\":\"A:A1IA7603\",\"pocket_id\":\"9f9k_A:A1IA7603\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"4p0r\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"4p0r\",\"reference_na_type\":\"DNA-bound\",\"reference_na_description\":\"DNA CTGTGTGTAAGCACG; DNA ACGTGCTTACACACAGAGGTTAGGGTGAACTT; DNA CAAGTTCACCCTAACCTCAG\",\"source_pocket_residue_count\":10,\"source_pocket_residue_set\":\"A:ARG334;A:ARG348;A:ASP307;A:ASP339;A:ASP346;A:GLN352;A:GLU333;A:LYS335;A:SER342;A:SER343\",\"source_hydrophobic_ratio\":0.0,\"source_positive_ratio\":0.3,\"mapped_uniprot_position_count\":10,\"reference_pocket_residue_count\":20,\"reference_pocket_residue_set\":\"A:ARG334;A:ARG348;A:ASP307;A:ASP339;A:ASP346;A:GLN352;A:GLU333;A:LYS335;A:SER342;A:SER343;C:ARG334;C:ARG348;C:ASP307;C:ASP339;C:ASP346;C:GLN352;C:GLU333;C:LYS335;C:SER342;C:SER343\",\"reference_hydrophobic_ratio\":0.0,\"reference_positive_ratio\":0.3,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.1117,\"global_ca_count\":180,\"pocket_rmsd_A\":0.6562,\"pocket_ca_count\":10,\"sequence_identity\":1.0,\"overlay_cif_file\":\"9f9k__4p0r__src-A__ref-A__A1IA7__A_A1IA7603__9f9k_A_A1IA7603__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/9f9k__4p0r__src-A__ref-A__A1IA7__A_A1IA7603__9f9k_A_A1IA7603__overlay.cif\"}]},{\"pdb_id\":\"9f9l\",\"pockets\":[{\"compound_name\":\"A1IA8\",\"ligand_instance\":\"A:A1IA8604\",\"pocket_id\":\"9f9l_A:A1IA8604\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[],\"na_contributing_pdb_ids\":[\"4p0r\",\"4p0s\"],\"reference_pdb_id\":\"4p0r\",\"reference_na_type\":\"DNA-bound\",\"reference_na_description\":\"DNA CTGTGTGTAAGCACG; DNA ACGTGCTTACACACAGAGGTTAGGGTGAACTT; DNA CAAGTTCACCCTAACCTCAG\",\"source_pocket_residue_count\":12,\"source_pocket_residue_set\":\"A:ARG334;A:ARG348;A:ARG355;A:ASP307;A:ASP339;A:ASP346;A:GLN352;A:GLU333;A:GLU351;A:LYS335;A:SER342;A:SER343\",\"source_hydrophobic_ratio\":0.0,\"source_positive_ratio\":0.3333,\"mapped_uniprot_position_count\":12,\"reference_pocket_residue_count\":24,\"reference_pocket_residue_set\":\"A:ARG334;A:ARG348;A:ARG355;A:ASP307;A:ASP339;A:ASP346;A:GLN352;A:GLU333;A:GLU351;A:LYS335;A:SER342;A:SER343;C:ARG334;C:ARG348;C:ARG355;C:ASP307;C:ASP339;C:ASP346;C:GLN352;C:GLU333;C:GLU351;C:LYS335;C:SER342;C:SER343\",\"reference_hydrophobic_ratio\":0.0,\"reference_positive_ratio\":0.3333,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.0862,\"global_ca_count\":184,\"pocket_rmsd_A\":0.4442,\"pocket_ca_count\":12,\"sequence_identity\":1.0,\"overlay_cif_file\":\"9f9l__4p0r__src-A__ref-A__A1IA8__A_A1IA8604__9f9l_A_A1IA8604__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/9f9l__4p0r__src-A__ref-A__A1IA8__A_A1IA8604__9f9l_A_A1IA8604__overlay.cif\"},{\"compound_name\":\"A1IA8\",\"ligand_instance\":\"A:A1IA8604\",\"pocket_id\":\"9f9l_A:A1IA8604\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[],\"na_contributing_pdb_ids\":[\"4p0r\",\"4p0s\"],\"reference_pdb_id\":\"4p0s\",\"reference_na_type\":\"DNA-bound\",\"reference_na_description\":\"DNA GAATGTGTGTCT; DNA TAGACACACATTCGGGACATGCAG; DNA TCTGCATGTCATT\",\"source_pocket_residue_count\":12,\"source_pocket_residue_set\":\"A:ARG334;A:ARG348;A:ARG355;A:ASP307;A:ASP339;A:ASP346;A:GLN352;A:GLU333;A:GLU351;A:LYS335;A:SER342;A:SER343\",\"source_hydrophobic_ratio\":0.0,\"source_positive_ratio\":0.3333,\"mapped_uniprot_position_count\":12,\"reference_pocket_residue_count\":48,\"reference_pocket_residue_set\":\"A:ARG334;A:ARG348;A:ARG355;A:ASP307;A:ASP339;A:ASP346;A:GLN352;A:GLU333;A:GLU351;A:LYS335;A:SER342;A:SER343;C:ARG334;C:ARG348;C:ARG355;C:ASP307;C:ASP339;C:ASP346;C:GLN352;C:GLU333;C:GLU351;C:LYS335;C:SER342;C:SER343;E:ARG334;E:ARG348;E:ARG355;E:ASP307;E:ASP339;E:ASP346;E:GLN352;E:GLU333;E:GLU351;E:LYS335;E:SER342;E:SER343;G:ARG334;G:ARG348;G:ARG355;G:ASP307;G:ASP339;G:ASP346;G:GLN352;G:GLU333;G:GLU351;G:LYS335;G:SER342;G:SER343\",\"reference_hydrophobic_ratio\":0.0,\"reference_positive_ratio\":0.3333,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"A\",\"global_rmsd_A\":1.1203,\"global_ca_count\":184,\"pocket_rmsd_A\":0.4998,\"pocket_ca_count\":12,\"sequence_identity\":1.0,\"overlay_cif_file\":\"9f9l__4p0s__src-A__ref-A__A1IA8__A_A1IA8604__9f9l_A_A1IA8604__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/9f9l__4p0s__src-A__ref-A__A1IA8__A_A1IA8604__9f9l_A_A1IA8604__overlay.cif\"}]}]","protein_name":"Structure-specific endonuclease subunit MUS81","protein_synonyms":"Crossover junction endonuclease MUS81; MUS81 endonuclease homolog","gene_name":"MUS81","gene_synonyms":"","organism_name":"Homo sapiens","uniprot_reviewed":"Reviewed","interpro_family":"IPR033309: Crossover junction endonuclease Mus81","interpro_domains":"IPR006166: ERCC4 domain; IPR010996: Crossover junction endonuclease MUS81-like, HHH domain; IPR047416: MUS81, XPF-like nuclease domain; IPR047417: MUS81, winged helix domain","interpro_homologous_superfamily":"IPR011335: Restriction endonuclease type II-like; IPR027421: DNA polymerase lambda lyase domain superfamily; IPR036388: Winged helix-like DNA-binding domain superfamily; IPR042530: EME1\/EME2, C-terminal domain","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"DNA\/RNA polymerase and replication protein","gpt_checked_class":"Nuclease \/ DNA-RNA repair enzyme","broad_class_reason":"matched keywords: dna polymerase, polymerase","all_matched_classes":"DNA\/RNA polymerase and replication protein [dna polymerase, polymerase] || Nuclease \/ DNA-RNA repair enzyme [endonuclease, mus81, nuclease]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}