{"id":827,"date":"2026-06-11T23:50:35","date_gmt":"2026-06-11T15:50:35","guid":{"rendered":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q9nsu2\/"},"modified":"2026-07-22T23:50:25","modified_gmt":"2026-07-22T15:50:25","slug":"q9nsu2","status":"publish","type":"proteins","link":"https:\/\/npi-disruptors.com\/index.php\/proteins\/q9nsu2\/","title":{"rendered":"Q9NSU2"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","class_list":["post-827","proteins","type-proteins","status-publish","hentry"],"acf":{"uniprot_id":"Q9NSU2","uniprot_related_pdbs":"9o0y","protein_pocket_json":"[{\"pdb_id\":\"9o0y\",\"pockets\":[{\"compound_name\":\"A1B7T\",\"ligand_instance\":\"A:A1B7T301\",\"pocket_id\":\"9o0y_A:A1B7T301\",\"cutoff_A\":4.0,\"na_match_pdb_ids\":[\"7tqq\"],\"na_contributing_pdb_ids\":[],\"reference_pdb_id\":\"7tqq\",\"reference_na_type\":\"DNA-bound\",\"reference_na_description\":\"DNA (5'-D(P*TP*TP*GP*GP*CP*CP*GP*GP*CP*CP*AP*TP*C)-3')\",\"source_pocket_residue_count\":15,\"source_pocket_residue_set\":\"A:ALA21;A:ALA80;A:ALA81;A:ASP130;A:GLU20;A:GLY23;A:ILE84;A:LEU133;A:LEU24;A:MET19;A:MET232;A:PRO25;A:PRO29;A:SER78;A:TYR129\",\"source_hydrophobic_ratio\":0.6667,\"source_positive_ratio\":0.0,\"mapped_uniprot_position_count\":15,\"reference_pocket_residue_count\":60,\"reference_pocket_residue_set\":\"A:ALA21;A:ALA80;A:ALA81;A:ASP130;A:GLU20;A:GLY23;A:ILE84;A:LEU133;A:LEU24;A:MET19;A:MET232;A:PRO25;A:PRO29;A:SER78;A:TYR129;B:ALA21;B:ALA80;B:ALA81;B:ASP130;B:GLU20;B:GLY23;B:ILE84;B:LEU133;B:LEU24;B:MET19;B:MET232;B:PRO25;B:PRO29;B:SER78;B:TYR129;E:ALA21;E:ALA80;E:ALA81;E:ASP130;E:GLU20;E:GLY23;E:ILE84;E:LEU133;E:LEU24;E:MET19;E:MET232;E:PRO25;E:PRO29;E:SER78;E:TYR129;F:ALA21;F:ALA80;F:ALA81;F:ASP130;F:GLU20;F:GLY23;F:ILE84;F:LEU133;F:LEU24;F:MET19;F:MET232;F:PRO25;F:PRO29;F:SER78;F:TYR129\",\"reference_hydrophobic_ratio\":0.6667,\"reference_positive_ratio\":0.0,\"source_alignment_chain\":\"A\",\"reference_alignment_chain\":\"B\",\"global_rmsd_A\":1.2422,\"global_ca_count\":213,\"pocket_rmsd_A\":0.3996,\"pocket_ca_count\":15,\"sequence_identity\":0.9765,\"overlay_cif_file\":\"9o0y__7tqq__src-A__ref-B__A1B7T__A_A1B7T301__9o0y_A_A1B7T301__overlay.cif\",\"overlay_cif_url\":\"https:\/\/npi-disruptors-structures.s3.us-east-2.amazonaws.com\/aligned_reference_cif\/9o0y__7tqq__src-A__ref-B__A1B7T__A_A1B7T301__9o0y_A_A1B7T301__overlay.cif\"}]}]","protein_name":"Three-prime repair exonuclease 1","protein_synonyms":"3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase III","gene_name":"TREX1","gene_synonyms":"","organism_name":"Homo sapiens","uniprot_reviewed":"Reviewed","interpro_family":"IPR040393: Three-prime repair exonuclease 1\/2","interpro_domains":"IPR013520: Ribonuclease H-like domain","interpro_homologous_superfamily":"IPR012337: Ribonuclease H-like superfamily; IPR036397: Ribonuclease H superfamily","pfam_domains":"","interpro_other_entries":"","broad_protein_class":"Nuclease \/ DNA-RNA repair enzyme","gpt_checked_class":"Nuclease \/ DNA-RNA repair enzyme","broad_class_reason":"matched keywords: exonuclease, nuclease, repair exonuclease, ribonuclease, three-prime repair exonuclease","all_matched_classes":"Nuclease \/ DNA-RNA repair enzyme [exonuclease, nuclease, repair exonuclease, ribonuclease, three-prime repair exonuclease]"},"_links":{"self":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins\/827","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/proteins"}],"about":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/types\/proteins"}],"wp:attachment":[{"href":"https:\/\/npi-disruptors.com\/index.php\/wp-json\/wp\/v2\/media?parent=827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}