Broad functional classification of 77 NPID-associated proteins based on InterPro family/domain annotations and manual curation.
| Broad protein class | Count | Percentage |
|---|---|---|
| RNA-binding / RNA metabolism protein | 17 | 22.1% |
| Nuclease / DNA-RNA repair enzyme | 13 | 16.9% |
| DNA/RNA polymerase and replication protein | 11 | 14.3% |
| Viral replication / viral nucleic-acid-related protein | 7 | 9.1% |
| tRNA-related enzyme | 6 | 7.8% |
| Other enzyme / miscellaneous | 6 | 7.8% |
| Transcription factor / transcription regulator | 5 | 6.5% |
| Translation / ribosomal protein | 5 | 6.5% |
| DNA/RNA modification or nucleotide metabolism enzyme | 4 | 5.2% |
| CRISPR-Cas / prokaryotic antiviral defense protein | 2 | 2.6% |
| Argonaute / RNAi-related protein | 1 | 1.3% |
| Total | 77 | 100% |