NPI Disruptors Database

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NPI Disruptor Database

A curated resource for small molecules that target nucleic acid–protein interaction interfaces.
This database is designed to support the discovery and analysis of potential NPI disruptors collected from experimentally resolved structures.

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Database Statistics

213 curated disruptor candidates
Protein targets and structural entries are being continuously organized and updated.

Explore the Database

  • Browse compounds by ligand name
  • Browse entries by PDB ID
  • Browse targets by protein or UniProt accession
  • Explore same-site binding candidates
  • View downloadable datasets and annotations

About This Resource

The NPI Disruptor Database focuses on small molecules that bind at or near nucleic acid–protein interaction interfaces.
It is intended as a research resource for studying potential disruptor molecules, interaction hotspots, structural features, and future machine learning applications in NPI-targeted drug discovery.

Contact / Citation

This resource is under active development.
For questions, collaboration, or citation information, please contact the database maintainer.